Is HIV the viral equivalent of Alcohol?
According to a new study, yes, it is! HIV apparently has the ability to not only kill off mature brain cells but also prevent the brain from fixing the damage!
Journal Results
In the latest Cell Stem Cell journal, the University of California (San Diego) performed found out after performing experiments on mice that HIV viral load had a direct relationship with the amount of brain damage occurring and the inability of the brain to repair the damage caused. Although it was already known that HIV has a protective protein coating called gp120 which kills normal brain cells by disrupting their internal chemistry, what was discovered is that this same protein also slows the production of new brain cells in the hippocampus. This is bad news as the hippocampus is responsible for processing memory and solidifying learned behavior/materials.
HIV induced dementia
One of the known symptoms of advanced HIV Disease is dementia but until now, the depth of the damage it caused to the brain wasn’t known. Before antiviral drugs where developed, patients suffering from full blown AIDS often had mental illness but as this was segregated to those who where already in a state of waste, it was hard to pinpoint cause and effect. The brain is like many organs in our body, it regenerates itself on a regular basis, optimizes its processes and adapts to new challenges but this process occurs over an extended period of time, HIV is too quick.
Ramifications
Well, although the triple drug cocktail and other medications help keep viral loads down as much as possible, they don’t travel as easily through the brain as other organs due to its complex structures. As a result, even though a patient may live longer, the compound effects of HIV on the brain may still produce dementia in an otherwise relatively healthy individual.
The Bottom Line
HIV Disease is really proving to be one tough cookie to not only crack but understand as well.
Buzzvia
http://news.bbc.co.uk/2/hi/health/6944255.stm
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